About Norgesic® Forte

What is Norgesic® Forte?

Norgesic® Forte is a multimodal agent. It is an opioid-free pain reliever that combines 3 medications into one pill to help relieve mild to moderate acute musculoskeletal pain.

Each Norgesic® Forte tablet contains the following:

Orphenadrine Citrate 50 mg - Orphenadrine is a muscle relaxant, which helps to reduce muscle tension and pain due to strains, overuse, and other injuries.

Aspirin 770 mg - Aspirin is a nonsteroidal anti-inflammatory drug (NSAID). Aspirin is effective in alleviating pain, swelling, and fevers.

Caffeine 60 mg - Caffeine is a stimulant. It is often combined with other pain medications, such as aspirin, to increase pain relief.

Norgesic Forte Tablets
Tablets are not actual size.


What level of musculoskeletal pain does Norgesic® Forte treat?

Norgesic® Forte is a multimodal agent for treatment of mild to moderate acute musculoskeletal pain.

Pain Scale

Aspirin should be used with extreme caution in the presence of peptic ulcers and coagulation abnormalities. Rare GI hemorrhage due to the aspirin content may be associated with the administration of Norgesic® Forte.



What role does caffeine play in Norgesic® Forte?

According to a Cochrane meta-analysis of more than 7,000 patients, caffeine was found to have a synergistic effect on pain relief when added as an analgesic adjuvant.

Caffeine in Orphengesic Forte and other commonly consumed beverages





Side Effects

Side effects of Norgesic® Forte Tablets are those seen with aspirin and caffeine or those usually associated with mild anti-cholinergic agents. These may include tachycardia, palpitation, urinary hesitancy or retention, dry mouth, blurred vision, dilation of the pupil, increased intraocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, and rarely, urticaria and other dermatosis. Infrequently, an elderly patient may experience some degree of confusion. Mild central excitation and occasional hallucinations may be observed. These mild side effects can usually be eliminated by reduction in dosage. One case of aplastic anemia associated with the use of orphenadrine citrate, aspirin and caffeine has been reported. No causal relationship has been established. Rare G.I. hemorrhage due to aspirin content may be associated with the administration of Norgesic® Forte Tablets. Some patients may experience transient episodes of light-headedness, dizziness or syncope.

Norgesic Forte Tablets
SCORED TABLET FOR A FLEXIBLE DOSING REGIMEN
Tablets are not actual size
½ to 1 tablet
3 to 4 times daily

References:
1. IQVIA and Symphony Health. Data on file.


What pharmacies carry Norgesic® Forte?

Norgesic® Forte is available at many independent and retail pharmacies. If you are unable to find this product locally, Sterling Specialty Pharmacy is able to mail to patients across the US. Should your healthcare provider choose to prescribe Norgesic® Forte, download the Sterling Specialty Pharmacy information sheet (PDF) to give to them.

E-scribe #: 2433693
Pharmacy Name: Sterling Specialty Pharmacy, Mendota Heights, MN
Phone Number: 888-618-4126
Fax Number: 866-588-0371






IMPORTANT SAFETY INFORMATION (ISI)

What is the most important information I should know about Norgesic® Forte?

Norgesic® Forte tablets may cause serious side effects, including:

  • Rare but serious bleeding due to the aspirin content
  • Life-threatening skin reactions
  • Life-threatening allergic reactions

Stop taking Norgesic® Forte and call your healthcare provider or get emergency help right away if you have any of these symptoms: rash, fever, trouble breathing, or swelling of the face, lips, tongue, or throat.

Use caution until you know how Norgesic® Forte affects you. It may impair your ability to drive or use other machinery.

Do not take Norgesic® Forte if you have any of the following:

  • Glaucoma (an eye disease)
  • Blockage in your digestive tract (pyloric or duodenal obstruction)
  • Achalasia (a rare disorder of the esophagus)
  • Enlarged prostate (prostatic hypertrophy)
  • Blockage that results in trouble urinating (obstruction of the bladder neck)
  • Myasthenia gravis (a disorder of the muscles and nerves)
  • Allergy or sensitivity to orphenadrine, aspirin, caffeine, or any other ingredient in Norgesic® Forte
    (see Full Prescribing Information (PDF) for complete list)

Before taking Norgesic® Forte, tell your healthcare provider about all your medical conditions, including active viral infection (such as chicken pox, flu, or flu-like symptoms), stomach ulcer, bleeding problems, or pregnancy (or plans to become pregnant).

Talk to your healthcare provider if you are considering taking Norgesic® Forte during pregnancy. You should not take Norgesic® Forte after 29 weeks of pregnancy.

What are the possible side effects of Norgesic® Forte?

Common side effects of Norgesic® Forte include increased heart rate (tachycardia), strong or rapid heartbeat (palpitations), trouble urinating (urinary hesitancy or retention), dry mouth, blurred vision, weakness, nausea, vomiting, headache, dizziness, constipation, or drowsiness.

These are not all the possible side effects of Norgesic® Forte. Please see the Full Prescribing Information (PDF) for the complete list of side effects or speak with your healthcare provider for medical advice or more information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

INDICATION

Norgesic® Forte is a prescription medicine for the relief of mild to moderate pain due to acute disorders of the muscles, bones, joints, ligaments, or tendons. Norgesic® Forte tablets should be used along with rest, physical therapy, and other measures to help relieve discomfort associated with such conditions. Norgesic® Forte is not recommended in children under 12 years of age.

Please see the Full Prescribing Information (PDF).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.